Excerpt from an excellent article, “Hidden Invaders. Infections can trigger immune Attacks on Kids’ brains, provoking destating psychiatric disorders,” by medical writer, Pamela Weintraub. This outlines the history of PANDAS-PANS and new BREAKTHRU research that shows the presence of three new discoveries:
autoantibodies in the brain (Cunningham, Univ of OK),immune cells that strep inspires, TH17 open the barrier to the brain (Agalliu, Columbia Univ), and, new lymphatic channels link the immune system to the brain (Kipnis, Univ of VA). This is neuroscience research in mice but translates well to this disease.
Funding for research is needed to continue to show it in the human model.